Mary Jane Watson is Peter Parker's neighbour, and later his wife.
Mary Jane is Peter Parker's crush from as far back as when he is six years old. She doesn't really notice him though. She dates Flash Thompson during their high school years. After she is rejected at an acting audition, she secretly begins working as a waitress at a diner. Mary Jane starts to date Harry Osborn after they graduated from high school. However, after being saved by Spider-Man multiple times, she develops a love for Peter's alter-ego. She and Spidey even share a kiss. As Harry tries to be loving towards her, she grows more distant from him, denying any advances he tries to make. While Peter and Mary Jane are talking in Aunt May's hospital room, Peter tells her what he supposedly told Spider-Man about her, which makes Mary Jane's feelings for Peter grow. After a couple of arguments, she breaks up with Harry.
Two years later, she is an actress and engaged to John Jameson, which leads Peter to give up being Spider-Man. However, Doctor Octopus captures her and forces Peter to become Spider-Man once again which ends up with him revealing his secret identity to them both. Mary Jane soon changed her mind and left John at the alter on her wedding day, deciding to start a relationship with Peter instead. When Peter thinks he is ready to ask her to marry him, he is taken over by a symbiote and leaves her for Gwen Stacy, which leads her to be kidnapped by Venom and Sandman. Peter rescues her and they restore their relationship at Harry's funeral.